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Article

CRISPR/Cas9 genome editing demonstrates functionality of the autoimmunity-associated SNP rs12946510.

Biochimica et biophysica acta. Molecular basis of disease - 1 Feb 2023

Ustiugova Alina S, Ekaterina Dvorianinova M, Nataliya Melnikova V, Alexey Dmitriev A, Dmitry Kuprash V, Marina Afanasyeva A

Abstract excerpt

Genome-wide association studies (GWAS) map genetic associations of complex traits with precision limited to a linkage disequilibrium group. To translate GWAS results into new understanding of disease mechanisms, individual causative polymorphisms and their target genes should be identified. CRISPR/Cas9 genome editing can be used to create isogenic cell lines bearing alternative genotypes of candidate...

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PMID: 36427699
DOI: 10.1016/j.bbadis.2022.166599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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