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Article

Cellular Biomechanic Impairment in Cardiomyocytes Carrying the Progeria Mutation: An Atomic Force Microscopy Investigation.

Langmuir : the ACS journal of surfaces and colloids - 6 Dec 2022

Peña Brisa, Gao Shanshan, Borin Daniele, Del Favero Giorgia, Abdel-Hafiz Mostafa, Farahzad Nasim, Lorenzon Paola, Sinagra Gianfranco, Taylor Matthew R G, Mestroni Luisa, Sbaizero Orfeo

Abstract excerpt

Given the clinical effect of progeria syndrome, understanding the cell mechanical behavior of this pathology could benefit the patient's treatment. Progeria patients show a point mutation in the lamin A/C gene (LMNA), which could change the cell's biomechanical properties. This paper reports a mechano-dynamic analysis of a progeria mutation (c.1824 C > T, p.Gly608Gly) in neonatal rat ventricular myocytes (NRVMs)...

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Share to Biomechanical Phenomena
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36420863
DOI: 10.1021/acs.langmuir.2c02623
PMCID: PMC9730902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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