Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations

31 Oct 2016

Abstract excerpt

Significance Defective prelamin A processing causes cardiovascular alterations and premature death in Hutchinson–Gilford progeria syndrome (HGPS) patients and also occurs during physiological aging. We found overt repolarization abnormalities in HGPS patients at advanced disease stages. Similar alterations were present in progeroid Zmpste24 −/− mice, which had cardiomyocytes that exhibited prolonged calcium...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nuclear Structure and Function
Share to PARP inhibition in cancer therapy
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27799555
DOI: 10.1073/pnas.1603754113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterationsPMID 27799555Read ↗

Paclitaxel mitigates structural alterations and cardiac conduction system defects in a mouse model of Hutchinson-Gilford progeria syndrome.Semantic proximity Read ↗

Molecular insights into the premature aging disease progeria.Semantic proximity Read ↗

Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy ActivationSemantic proximity Read ↗

Premature aging syndromes: From patients to mechanism.Semantic proximity Read ↗

Recent advances in animal and human pluripotent stem cell modeling of cardiac laminopathy.Semantic proximity Read ↗

Molecular and Cellular Mechanisms Driving Cardiovascular Disease in Hutchinson-Gilford Progeria Syndrome: Lessons Learned from Animal Models.Semantic proximity Read ↗

Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis.Semantic proximity Read ↗

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation.Semantic proximity Read ↗

Generation and characterization of a novel knockin minipig model of Hutchinson-Gilford progeria syndromeSemantic proximity Read ↗

Hutchinson-Gilford Progeria Syndrome: A Literature ReviewSemantic proximity Read ↗

The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria SyndromeSemantic proximity Read ↗

Metabolic Dysfunction in Hutchinson–Gilford Progeria SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.