Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ECM1 regulates the resistance of colorectal cancer to 5-FU treatment by modulating apoptotic cell death and epithelial-mesenchymal transition induction

2 Nov 2022

Abstract excerpt

5-Fluorouracil (5-FU) chemoresistance is a persistent impediment to the efficient treatment of many types of cancer, yet the molecular mechanisms underlying such resistance remain incompletely understood. Here we found CRC patients resistant to 5-FU treatment exhibited increased extracellular matrix protein 1 (ECM1) expression compared to CRC patients sensitive to this chemotherapeutic agent, and higher levels of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related Molecular Pathways
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36408224
DOI: 10.3389/fphar.2022.1005915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ECM1 regulates the resistance of colorectal cancer to 5-FU treatment by modulating apoptotic cell death and epithelial-mesenchymal transition inductionPMID 36408224Read ↗

Extracellular Matrix Protein 1 Regulates Colorectal Cancer Cell Proliferative, Migratory, Invasive and Epithelial-Mesenchymal Transition Activities Through the PI3K/AKT/GSK3β/Snail Signaling AxisSemantic proximity Read ↗

The role of GLI1 for 5-Fu resistance in colorectal cancerSemantic proximity Read ↗

FOXM1 evokes 5-fluorouracil resistance in colorectal cancer depending on ABCC10Semantic proximity Read ↗

Evaluation of the Prognostic Value of Four ECM-Associated Genes in Recurrence and Metastasis of Colorectal CancerSemantic proximity Read ↗

HMBOX1 reverses autophagy mediated 5-fluorouracil resistance through promoting HACE1-induced ubiquitination and degradation of ATG5 in colorectal cancerSemantic proximity Read ↗

GDF15 promotes 5-Fluorouracil and Oxaliplatin resistance by promoting stem cell-like phenotype in colorectal cancer.Semantic proximity Read ↗

HIF1α/VEGF Feedback Loop Contributes to 5-Fluorouracil ResistanceSemantic proximity Read ↗

Early-stage colon cancer with high MALAT1 expression is associated with the 5-Fluorouracil resistance and future metastasisSemantic proximity Read ↗

Overcoming Therapy Resistance in Colorectal Cancer: Targeting Rac1 Signaling Pathway as a Potential Therapeutic ApproachSemantic proximity Read ↗

Wnt5a suppresses colorectal cancer progression via TGF-β/NOTUM/OLFM4 axis in patient-derived organoidsSemantic proximity Read ↗

Development of gemcitabine-modified miR-15a as a novel, multimodal treatment strategy to overcome 5-FU and oxaliplatin resistance in colorectal cancerSemantic proximity Read ↗

Decreased expression of miR‑3135b reduces sensitivity to 5‑fluorouracil in colorectal cancer by direct repression of PIM1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.