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HIF1α/VEGF Feedback Loop Contributes to 5-Fluorouracil Resistance

9 Mar 2022

Abstract excerpt

5-Fluorouracil (5-Fu) is one of the basic drugs in colorectal cancer (CRC) chemotherapy, and its efficacy is mainly limited by the acquisition of drug resistance. However, the underlying mechanisms remain unclear. In this study, hypoxia inducible factor 1α (HIF1α) was screened for high expression in 5-Fu resistant HCT115 cells, which displayed epithelial-mesenchymal transition (EMT) phenotype. Suppression of...

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PMID: 35355718
DOI: 10.3389/fphar.2022.851401

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