Article
Path: a tool to facilitate pathway-based genetic association analysis.
Bioinformatics (Oxford, England) - 15 Sept 2009
Zamar David, Tripp Ben, Ellis George, Daley Denise
Abstract excerpt
SUMMARY: Traditional methods of genetic study design and analysis work well under the scenario that a handful of single nucleotide polymorphisms (SNPs) independently contribute to the risk of disease. For complex diseases, susceptibility may be determined not by a single SNP, but rather a complex interplay between SNPs. For large studies involving hundreds of thousands of SNPs, a brute force search of all...
Topics
- Computational Biology
- Databases, Factual
- Genome-Wide Association Study
- Internet
- Polymorphism, Single Nucleotide
- Software