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Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells

28 Sept 2021

Abstract excerpt

DNA repair promotes the progression and recurrence of glioblastoma (GBM). However, there remain no effective therapies for targeting the DNA damage response and repair (DDR) pathway in the clinical setting. Thus, we aimed to conduct a comprehensive analysis of DDR genes in GBM specimens to understand the molecular mechanisms underlying treatment resistance. Herein, transcriptomic analysis of 177 well-defined DDR...

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Share to Epigenetics and DNA Methylation
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PMID: 34584069
DOI: 10.1038/s41419-021-04182-w

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