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Article

Proteomic genotyping of SNP of Complement Factor H (CFH) Y402H and I62V using multiple reaction monitoring (MRM) assays.

Scientific reports - 15 Nov 2022

Kim Kyoung Lae, Kim Hyerim, Lee Youngju, Lee Cheolju, Joo Kwangsic, Park Sang Jun, Park Kyu Hyung, Park Seong-Jun, Woo Se Joon

Abstract excerpt

The single nucleotide polymorphisms (SNPs) of complement factor H (CFH) gene are well-known genetic risk factors for age-related macular degeneration (AMD). To identify whether the measurement of plasma protein concentrations of CFH variants using the multiple reaction monitoring (MRM) assay can determine the genotypes of CFH SNP rs1061170 and rs800292, 120 patients with AMD and 26 controls were included in this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36379987
DOI: 10.1038/s41598-022-20936-8
PMCID: PMC9666549

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