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Article

Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration.

Investigative ophthalmology & visual science - 1 May 2008

Hakobyan Svetlana, Harris Claire L, Tortajada Agustín, Goicochea de Jorge Elena, García-Layana Alfredo, Fernández-Robredo Patricia, Rodríguez de Córdoba Santiago, Morgan B Paul

Abstract excerpt

PURPOSE: The Y402H polymorphism in the complement regulator factor H (fH) is strongly associated with age-related macular degeneration (AMD) across diverse populations. Persons homozygous for histidine at this position have up to 12-fold greater risk for AMD than those homozygous for tyrosine. Knowledge of fH-Y402H status is, therefore, valuable in predicting risk and focusing preventive measures in the elderly....

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PMID: 18436830
DOI: 10.1167/iovs.07-1523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration.PMID 18436830Read ↗

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