Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel association of FCGR2A polymorphism with age-related macular degeneration (AMD) and development of a novel CFH real-time genotyping method.

Clinical chemistry and laboratory medicine - 1 Sept 2015

Velissari Aliki, Skalidakis Iosif, Oliveira Samantha C, Koutsandrea Chryssanthi, Kitsos George, Petersen Michael B, Kroupis Christos

Abstract excerpt

BACKGROUND: Age-related macular degeneration (AMD) is a degenerative ocular disease, which may lead to loss of central vision. In Caucasian populations, a strong correlation has been established with polymorphism Y402H (rs1061170) in the complement factor H gene (CFH). The H131R polymorphism (rs1801274) in the FCGR2A gene has been associated with many inflammatory diseases, but has not been investigated in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Factor H
Share to Genotyping Techniques
Share to Macular Degeneration
Share to Real-Time Polymerase Chain Reaction
Share to Receptors, IgG
Share to Reproducibility of Results
Share to Sequence Analysis, DNA
Share to White People

Source

Identifiers

PMID: 25811666
DOI: 10.1515/cclm-2014-0920

Genes

CFH

Variants

rs1801274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel association of FCGR2A polymorphism with age-related macular degeneration (AMD) and development of a novel CFH real-time genotyping method.PMID 25811666Read ↗

Polymorphism p.402Y>H in the complement factor H protein is a risk factor for age related macular degeneration in an Italian population.Semantic proximity Read ↗

Association between Y402H, E318D and R102G polymorphisms of complement proteins genes and the response to intravitreal anti-VEGF treatment in patients with neovascular age-related macular degeneration.Semantic proximity Read ↗

Association of complement factor H Y402H polymorphism and age-related macular degeneration in Brazilian patients.Semantic proximity Read ↗

Association of the Y402H polymorphism in complement factor H gene and neovascular age-related macular degeneration in Chinese patients.Semantic proximity Read ↗

Analysis of complement factor H Y402H, LOC387715, HTRA1 polymorphisms and ApoE alleles with susceptibility to age-related macular degeneration in Hungarian patients.Semantic proximity Read ↗

Complement factor H and LOC387715 gene polymorphisms in a Greek population with age-related macular degeneration.Semantic proximity Read ↗

A rare penetrant mutation in CFH confers high risk of age-related macular degeneration.Semantic proximity Read ↗

Genetic Variants of Complement Factor H Y402H (rs1061170), C2 R102G (rs2230199), and C3 E318D (rs9332739) and Response to Intravitreal Anti-VEGF Treatment in Patients with Exudative Age-Related Macular Degeneration.Semantic proximity Read ↗

Investigating the CFH Gene Polymorphisms as a Risk Factor for Age-related Macular Degeneration in an Iranian Population.Semantic proximity Read ↗

Association of the Complement Factor H Y402H Polymorphism and Response to Anti-Vascular Endothelial Growth Factor Treatment in Age-Related Macular Degeneration: An Updated Meta-Analysis.Semantic proximity Read ↗

[The pharmacogenomics of CFH Y402H and wet age-related macular degeneration].Semantic proximity Read ↗

CFH polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.