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Article

The viral nucleoprotein determines Mx sensitivity of influenza A viruses.

Journal of virology - 1 Aug 2011

Zimmermann Petra, Mänz Benjamin, Haller Otto, Schwemmle Martin, Kochs Georg

Abstract excerpt

Host restriction factors play a crucial role in preventing trans-species transmission of viral pathogens. In mammals, the interferon-induced Mx GTPases are powerful antiviral proteins restricting orthomyxoviruses. Hence, the human MxA GTPase may function as an efficient barrier against zoonotic introduction of influenza A viruses into the human population. Successful viruses are likely to acquire adaptive...

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Identifiers

PMID: 21680506
DOI: 10.1128/JVI.00712-11
PMCID: PMC3147989

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