Association of Polymorphism of the Methyl Tetrahydrofolate Reductase (MTHFR) Gene with Anti-Seizure Medication Response in Pediatric Patients in Jeddah, Saudi Arabia.

doi:10.3390/medicina58111593

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Article

Association of Polymorphism of the Methyl Tetrahydrofolate Reductase (MTHFR) Gene with Anti-Seizure Medication Response in Pediatric Patients in Jeddah, Saudi Arabia.

Medicina (Kaunas, Lithuania) - 3 Nov 2022

Alyoubi Reem, Althomali Abdullah, Magadmi Rania, Abdel Kawy Hala S, Al Mahdi Hadiah Bassam, Kamel Fatemah O, Bakhshwin Duaa M, Jamal Maha, Alsieni Mohammed

Abstract excerpt

Background and ObjectivesEpilepsy is a chronic brain disease, with inherent and noninherent factors. Although over 20 anti-seizure medications (ASMs) are commercially available, nearly one-third of patients develop drug-resistant epilepsy. We evaluated the association between the clinical features and the methyl tetrahydrofolate (MTHFR) rs1801133 polymorphism and ASMs response among pediatric patients with...

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PMID: 36363550
DOI: 10.3390/medicina58111593
PMCID: PMC9698893

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