Positive selection-driven fixation of a hominin-specific amino acid mutation related to dephosphorylation in IRF9.

Abstract excerpt

The arms race between humans and pathogens drives the evolution of the human genome. It is thus expected that genes from the interferon-regulatory factors family (IRFs), a critical family for anti-viral immune response, should be undergoing episodes of positive selection. Herein, we tested this hypothesis and found multiple lines of evidence for positive selection on the amino acid site Val129...

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