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Article

Nearly neutral evolution in IFNL3 gene retains the immune function to detect and clear the viral infection in HCV.

Progress in biophysics and molecular biology - 1 Dec 2018

Singh Pratichi, Dass J Febin Prabhu

Abstract excerpt

IFNL3 gene plays a crucial role in immune defense against viruses. It induces the interferon stimulated genes (ISGs) with antiviral properties by activating the JAK-STAT pathway. In this study, we investigated the evolutionary force involved in shaping the IFNL3 gene to perform its downstream function as a regulatory gene in HCV clearance. We have selected 25 IFNL3 coding sequences with human gene as a reference...

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Source

Identifiers

PMID: 29746888
DOI: 10.1016/j.pbiomolbio.2018.05.004

Genes

IFNL3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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