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Clostridioides difficile S-Layer Protein A (SlpA) Serves as a General Phage Receptor

15 Feb 2023

Abstract excerpt

have a narrow host range and target members from only one or a few PCR ribotypes. Without a clear comprehension of the factors that define host specificity, and in particular the host receptor recognized by phages, it is hard to develop therapeutic cocktails in a rational manner. In our study, we provide clear and unambiguous experimental evidence that SlpA is a common receptor used by many siphophages and...

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PMID: 36790200
DOI: 10.1128/spectrum.03894-22

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