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Article

Is there a specific phenotype associated with the different subtypes of KRAS mutations in patients with advanced non-small-cell lung cancers?

Lung cancer (Amsterdam, Netherlands) - 1 Dec 2015

Dumenil Coraline, Vieira Thibault, Rouleau Etienne, Antoine Martine, Duruisseaux Michael, Poulot Virginie, Lacave Roger, Cadranel Jacques, Massiani Marie-Ange, Wislez Marie

Abstract excerpt

OBJECTIVES: KRAS mutations occur in 20 to 25% of non-small-cell lung cancers (NSCLC) and seem to predict a poor prognosis. There is heterogeneousness in the frequency and spectrum of KRAS mutations, which can be categorized in transitions and transversions. We wondered if subtypes of KRAS mutation were associated with specific clinical phenotypes and specific survival. MATERIALS AND METHODS: Between July 2007 and...

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PMID: 26520186
DOI: 10.1016/j.lungcan.2015.10.012

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KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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