Clinical phenotypes of difficult-to-treat and mild asthma defined by cluster analysis.

doi:10.1186/s12931-026-03740-0

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Article

Clinical phenotypes of difficult-to-treat and mild asthma defined by cluster analysis.

Respiratory research - 29 May 2026

Leily Mohammad, Mistry Heena, Zhang Hongmei, Larsson Maria, Varkonyi-Sepp Judit, Ainsworth Ben, Wei Liuyu, Eames Chellan, Hudson-Colby J J, Lewis Adam, Freeman Anna, Haitchi Hans Michael, Dennison Paddy, Djukanovic Ratko, La Mata Sara Herrera-De, Seumois Grégory, Vijayanand Pandurangan, Kyyaly Mohammed A, Vorobeva Elena, Dabrio-Reina Elena, Arshad Syed Hasan, Kurukulaaratchy Ramesh J

Abstract excerpt

BACKGROUND: Cluster modelling has demonstrated asthma heterogeneity across disease severities, but contemporary data integrating difficult-to-treat and mild asthma with systematic assessment of comorbidity-focused treatable traits remain limited. OBJECTIVE: To identify and characterise difficult-to-treat and mild asthma clusters in two UK cohorts: Wessex AsThma CoHort of Difficult Asthma (WATCH-DA) and a...

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PMID: 42216135
DOI: 10.1186/s12931-026-03740-0
PMCID: PMC13480206

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