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Article

Context-specific genetic effects inform endotypes and treatment in asthma.

The Journal of allergy and clinical immunology - 1 Jul 2026

Dahl Andy, Sajuthi Satria, Rappaport Nadav, Galanter Joshua, Gignoux Chris, Burchard Esteban, Seibold Max, Zaitlen Noah

Abstract excerpt

BACKGROUND: Asthma has heterogeneous risk factors, subtypes, and treatments. It is often unclear how to stratify this heterogeneity in scientific studies and clinical care. Genetics could explain root causes of this clinical heterogeneity, called endotypes, but prior studies have used models that are not designed for complex diseases like asthma. OBJECTIVE: We aimed to find genetic effects that partly explain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41935671
DOI: 10.1016/j.jaci.2026.03.017
PMCID: PMC13218556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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