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Article

T cell-inflamed gene expression profile is associated with favorable disease-specific survival in non-hypermutated microsatellite-stable colorectal cancer patients.

Cancer medicine - 1 Mar 2023

Yin Hang, Harrison Tabitha A, Thomas Sushma S, Sather Cassie L, Koehne Amanda L, Malen Rachel C, Reedy Adriana M, Wurscher Michelle A, Hsu Li, Phipps Amanda I, Zaidi Syed H E, Newcomb Polly A, Peters Ulrike, Huyghe Jeroen R

Abstract excerpt

BACKGROUND: The anti-tumor immune response plays a key role in colorectal cancer (CRC) progression and survival. The T cell-inflamed gene expression profile (GEP) is a biomarker predicting response to checkpoint inhibitor immunotherapy across immunogenic cancer types, but the prognostic value in CRC is unknown. We evaluated associations with disease-specific survival, somatic mutations, and examined its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36341526
DOI: 10.1002/cam4.5429
PMCID: PMC10067089

Genes

APC
AREG
EPCAM
ITGA6
RPL23
RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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