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Article

Senescence of Primary Amniotic Cells via Oxidative DNA Damage

27 Dec 2013

Abstract excerpt

OBJECTIVE: Oxidative stress is a postulated etiology of spontaneous preterm birth (PTB) and preterm prelabor rupture of the membranes (pPROM); however, the precise mechanistic role of reactive oxygen species (ROS) in these complications is unclear. The objective of this study is to examine impact of a water soluble cigarette smoke extract (wsCSE), a predicted cause of pregnancy complications, on human amnion...

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PMID: 24386195
DOI: 10.1371/journal.pone.0083416

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