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Telomere Fragment Induced Amnion Cell Senescence: A Contributor to Parturition?

23 Sept 2015

Abstract excerpt

Oxidative stress (OS)-induced senescence of the amniochorion has been associated with parturition at term. We investigated whether telomere fragments shed into the amniotic fluid (AF) correlated with labor status and tested if exogenous telomere fragments (T-oligos) could induce human and murine amnion cell senescence. In a cross-sectional clinical study, AF telomere fragment concentrations quantitated by a...

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PMID: 26397719
DOI: 10.1371/journal.pone.0137188

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