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Article

Waldenström macroglobulinemia whole genome reveals prolonged germinal center activity and late copy number aberrations.

Blood advances - 28 Mar 2023

Maclachlan Kylee H, Bagratuni Tina, Kastritis Efstathios, Ziccheddu Bachisio, Lu Sydney, Yellapantula Venkata, Famulare Chris, Argyropoulos Kimon, Derkach Andriy, Papaemmanuil Elli, Dogan Ahmet, Lesokhin Alexander, Usmani Saad Z, Landgren C Ola, Palomba Lia M, Maura Francesco, Dimopoulos Meletios A

Abstract excerpt

The genomic landscape of Waldenström macroglobulinemia (WM) is characterized by somatic mutations in MYD88, present from the precursor stages. Using the comprehensive resolution of whole genome sequencing (WGS) in 14 CD19-selected primary WM samples; comparing clonal and subclonal mutations revealed that germinal center (GC) mutational signatures SBS9 (poly-eta) and SBS84 (AID) have sustained activity, suggesting...

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Identifiers

PMID: 36332058
DOI: 10.1182/bloodadvances.2022008876
PMCID: PMC10027506

Genes

GC
MYD88
CD19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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