Article
Genomic Landscape of Waldenström Macroglobulinemia.
Hematology/oncology clinics of North America - 1 Oct 2018
Treon Steven P, Xu Lian, Liu Xia, Hunter Zachary R, Yang Guang, Castillo Jorge J
Abstract excerpt
Next-generation sequencing has revealed recurring somatic mutations in Waldenström macroglobulinemia (WM). Common mutations include MYD88 (95%-97%), as well as CXCR4 (30%-40%), ARID1A (17%), and CD79B (8%-15%), which are typically found in MYD88-mutated patients. The genomic findings provide important insights into the pathogenesis, prognostication, and treatment outcome in WM. We discuss the genomic landscape of...
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