Article
The importance of the genomic landscape in Waldenström's Macroglobulinemia for targeted therapeutical interventions.
Oncotarget - 23 May 2017
Sacco Antonio, Fenotti Adriano, Affò Loredana, Bazzana Stefano, Russo Domenico, Presta Marco, Malagola Michele, Anastasia Antonella, Motta Marina, Patterson Christopher J, Rossi Giuseppe, Imberti Luisa, Treon Steven P, Ghobrial Irene M, Roccaro Aldo M
Abstract excerpt
The Literature has recently reported on the importance of genomics in the field of hematologic malignancies, including B-cell lymphoproliferative disorders such as Waldenström's Macrolgobulinemia (WM). Particularly, whole exome sequencing has led to the identification of the MYD88L265P and CXCR4C1013G somatic variants in WM, occurring in about 90% and 30% of the patients, respectively. Subsequently, functional...
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