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A multiomic analysis of Waldenström macroglobulinemia defines distinct disease subtypes.

Blood - 4 Sept 2025

Gagler Dylan C, Ghamlouch Hussein, Zhang Di, Blaney Patrick, Tenenbaum Avital, Langton James, Armand Marine, Eeckhoutte Alexandre, Joudat Amina, Degaud Michaël, Esposito Michela, Varma Gaurav, Wang Yubao, Lee Sanghoon, Liu Sanxiong, Lahoud Oscar, Kaminetzky David, Braunstein Marc, Williams Louis, Nguyen-Khac Florence, Walker Brian, Roos-Weil Damien, Davies Faith E, Bernard Olivier A, Morgan Gareth J

Abstract excerpt

ABSTRACT: We carried out a single-cell multiomic analysis on a series of MYD88-mutated Waldenström macroglobulinemia (WM) patients and identified 2 distinct subtypes of disease, memory B-cell (MBC)-like and plasma cell (PC)-like, based on their expression of key lineage defining genes. Biologically, the subtypes are characterized by their variable capacity to differentiate fully toward a PC and exhibit unique...

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Source

Identifiers

PMID: 40332467
DOI: 10.1182/blood.2024028164

Genes

PC
ARID1A
BCL11A
CXCR4
MYD88
SPI1
SPIB
XBP1

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