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Article

From Waldenström's macroglobulinemia to aggressive diffuse large B-cell lymphoma: a whole-exome analysis of abnormalities leading to transformation.

Blood cancer journal - 25 Aug 2017

Jiménez C, Alonso-Álvarez S, Alcoceba M, Ordóñez G R, García-Álvarez M, Prieto-Conde M I, Chillón M C, Balanzategui A, Corral R, Marín L A, Gutiérrez N C, Puig N, Sarasquete M E, González M, García-Sanz R

Abstract excerpt

Transformation of Waldenström's macroglobulinemia (WM) to diffuse large B-cell lymphoma (DLBCL) occurs in up to 10% of patients and is associated with an adverse outcome. Here we performed the first whole-exome sequencing study of WM patients who evolved to DLBCL and report the genetic alterations that may drive this process. Our results demonstrate that transformation depends on the frequency and specificity of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28841204
DOI: 10.1038/bcj.2017.72
PMCID: PMC5596383

Genes

FRYL
PIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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