Article
The genomic landscape of Waldenstrom macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis.
Blood - 13 Mar 2014
Hunter Zachary R, Xu Lian, Yang Guang, Zhou Yangsheng, Liu Xia, Cao Yang, Manning Robert J, Tripsas Christina, Patterson Christopher J, Sheehy Patricia, Treon Steven P
Abstract excerpt
The genetic basis for Waldenström macroglobulinemia (WM) remains to be clarified. Although 6q losses are commonly present, recurring gene losses in this region remain to be defined. We therefore performed whole genome sequencing (WGS) in 30 WM patients, which included germline/tumor sequencing for 10 patients. Validated somatic mutations occurring in >10% of patients included MYD88, CXCR4, and ARID1A that were...
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