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Article

Nuclear localization of human MEIOB requires its NLS in the OB domain and interaction with SPATA22.

Acta biochimica et biophysica Sinica - 25 Nov 2022

Xu Yating, Chen Zhen, Wu Panfeng, Qu Wei, Shi Hanqing, Cheng Muyang, Xu Yumin, Jin Tingyu, Liu Cong, Li Yi, Luo Mengcheng

Abstract excerpt

MEIOB is a vital protein in meiotic homologous recombination and plays an indispensable role in human gametogenesis. In mammals, MEIOB and its partner SPATA22 form a heterodimer, ensuring their effective localization on single-strand DNA (ssDNA) and proper synapsis processes. Mutations in human MEIOB (hMEIOB) cause human infertility attributed to the failure of its interaction with human SPATA22 (hSPATA22) and...

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Identifiers

PMID: 36331299
DOI: 10.3724/abbs.2022156
PMCID: PMC10157540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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