Article
Dissecting the structural basis of MEIG1 interaction with PACRG.
Scientific reports - 4 Jan 2016
Li Wei, Walavalkar Ninad M, Buchwald William A, Teves Maria E, Zhang Ling, Liu Hong, Bilinovich Stephanie, Peterson Darrell L, Strauss Jerome F, Williams David C, Zhang Zhibing
Abstract excerpt
The product of the meiosis-expressed gene 1 (MEIG1) is found in the cell bodies of spermatocytes and recruited to the manchette, a structure unique to elongating spermatids, by Parkin co-regulated gene (PACRG). This complex is essential for targeting cargo to the manchette during sperm flagellum assembly. Here we show that MEIG1 adopts a unique fold that provides a large surface for interacting with other...
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