Article

Transient residence of the repulsive client Shutdown in Yb bodies plays a critical role in Piwi-piRISC biogenesis and maintaining fertility

2024-11-15

Abstract excerpt

<h4>Summary</h4> Nonmembranous organelles, such as Yb bodies in Drosophila ovarian somatic cells, form through liquid-liquid phase separation of scaffold proteins. Client proteins transiently accumulate in these organelles by binding to scaffolds. However, the regulation of this process is not well understood. Here, we investigate Shutdown, a client protein in Yb bodies, the site of Piwi-piRISC precursor (pre-Pi...

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Literature Corpus work: 16e8a742-a72d-5c05-a7c4-627b9c95fe42
DOI: 10.1101/2024.11.13.623522

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