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Apolipoprotein E imbalance in the cerebrospinal fluid of Alzheimer's disease patients.

Alzheimer's research & therapy - 2 Nov 2022

Lennol Matthew Paul, Sánchez-Domínguez Irene, Cuchillo-Ibañez Inmaculada, Camporesi Elena, Brinkmalm Gunnar, Alcolea Daniel, Fortea Juan, Lleó Alberto, Soria Guadalupe, Aguado Fernando, Zetterberg Henrik, Blennow Kaj, Sáez-Valero Javier

Abstract excerpt

OBJECTIVE: The purpose of this study was to examine the levels of cerebrospinal fluid (CSF) apolipoprotein E (apoE) species in Alzheimer's disease (AD) patients. METHODS: We analyzed two CSF cohorts of AD and control individuals expressing different APOE genotypes. Moreover, CSF samples from the TgF344-AD rat model were included. Samples were run in native- and SDS-PAGE under reducing or non-reducing conditions...

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Identifiers

PMID: 36324176
DOI: 10.1186/s13195-022-01108-2
PMCID: PMC9628034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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