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Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients.

BMC cancer - 2 Nov 2022

Li Yan, Chen Lili, Lv Jinxing, Chen Xiaobin, Zeng Bangwei, Chen Minyan, Guo Wenhui, Lin Yuxiang, Yu Liuwen, Hou Jialin, Li Jing, Zhou Peng, Zhang Wenzhe, Li Shengmei, Jin Xuan, Cai Weifeng, Zhang Kun, Huang Yeyuan, Wang Chuan, Fu Fangmeng

Abstract excerpt

BACKGROUND: Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit from poly (ADP-ribose) polymerase (PARP) inhibitors. However, formal genetic testing could not be carried out for all patients due to extensive use of healthcare resources, which in turn...

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Identifiers

PMID: 36324133
DOI: 10.1186/s12885-022-10160-y
PMCID: PMC9628090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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