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BRCA1 and BRCA2 germline mutations in Chinese Hakka breast cancer patients.

BMC medical genomics - 2 Jan 2024

Zhang Yinmei, Wu Heming, Gan Caiyan, Rao Hui, Wang Qiuming, Guo Xueming

Abstract excerpt

OBJECTIVE: To investigate the prevalence of BRCA1/2 gene variants and evaluate the clinical and pathological characteristics associated with these variants in Chinese Hakka breast cancer patients. METHODS: A total of 409 breast cancer patients were analyzed based on next-generation sequencing results, with 337 categorized as non-carriers and 72 as carriers of BRCA1/2 variants. Data on the patients' BRCA1/2 gene...

Topics

BRCA2 Protein
Germ-Line Mutation
East Asian People
Female
Ki-67 Antigen
Humans
Breast Neoplasms
China
Genetic Predisposition to Disease
BRCA1 Protein

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PMID: 38167124
DOI: 10.1186/s12920-023-01772-9
PMCID: PMC10763220

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