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Risk of second non-breast primary cancer in Chinese breast cancer patients with germline BRCA1/2 pathogenic variants.

Breast cancer research and treatment - 6 Jan 2026

Liu Jiaming, Chu Futao, Yao Lu, Sun Jie, Chen Jiuan, Zhang Juan, Xu Ye, Xie Yuntao

Abstract excerpt

PURPOSE: The risk of second non-breast primary cancer in Chinese women with breast cancer who carry germline BRCA1/2 pathogenic variants (PVs) is largely unknown. METHODS: From October 2003 to February 2023, 11,212 women with breast cancer were recruited. BRCA1/2 mutation status of these patients was determined; the age-specific cumulative risk of second non-breast primary cancer was estimated. RESULTS: Of the...

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Identifiers

PMID: 41493635
DOI: 10.1007/s10549-025-07886-1

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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