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Article

Predicting the likelihood of BRCA1/2 germline pathogenic variants in unselected patients with breast cancer: analysis of more than 10,000 individuals.

Journal of medical genetics - 27 Jan 2025

Sun Jie, Yao Lu, Chen Jiuan, Hu Li, Zhang Juan, Xu Ye, Xie Yuntao

Abstract excerpt

BACKGROUND: Models for accurately predicting the likelihood of BRCA1/2 germline pathogenic variants (PVs) based on a large cohort of unselected patients with breast cancer are limited. METHODS: A logistic regression model to predict the BRCA1/2 carrier probability, named PKCBRCA, was established and validated based on 10 167 unselected Chinese patients with breast cancer treated in Peking University Cancer...

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Identifiers

PMID: 39663109
DOI: 10.1136/jmg-2024-110332

Genes

BRCA1
ERBB2

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