Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation in the IL1B, TNF and IL6 genes and individual susceptibility to prosthetic joint infection.

BMC immunology - 8 May 2012

Stahelova Anna, Mrazek Frantisek, Smizansky Matej, Petrek Martin, Gallo Jiri

Abstract excerpt

BACKGROUND: Prosthetic joint infection (PJI) is an important failure mechanism of total joint arthroplasty (TJA). Here we examine whether the particular genetic variants can lead to increased susceptibility to PJI development. RESULTS: We conducted a genetic-association study to determine whether PJI could be associated with functional cytokine gene polymorphisms (CGP) influencing on innate immunity response. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Interleukin-1beta

Share to Interleukin-6

Share to Prosthesis-Related Infections

Share to Tumor Necrosis Factor-alpha

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 22568934
DOI: 10.1186/1471-2172-13-25
PMCID: PMC3475038

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in the IL1B, TNF and IL6 genes and individual susceptibility to prosthetic joint infection.PMID 22568934Read ↗

Genetic variation in key molecules of the Th-17 immune response is not associated with risk for prosthetic joint infection in a Czech population.Semantic proximity Read ↗

Single nucleotide polymorphisms in the development of osteomyelitis and prosthetic joint infection: a narrative review.Semantic proximity Read ↗

Genetic susceptibility to prosthetic joint infection following total joint arthroplasty: A systematic review.Semantic proximity Read ↗

Interleukin-1β Polymorphisms Are Genetic Markers of Susceptibility to Periprosthetic Joint Infection in Total Hip and Knee Arthroplasty.Semantic proximity Read ↗

Influence of interleukin 1alpha (IL-1alpha), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis.Semantic proximity Read ↗

Proinflammatory cytokine gene polymorphisms and susceptibility to Paget's disease of bone: an association study.Semantic proximity Read ↗

Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection.Semantic proximity Read ↗

Osteoprotegerin gene polymorphism is not associated with prosthetic joint infection after total joint arthroplasty in the Czech population.Semantic proximity Read ↗

Assessment of IL-10, IL-1ß and TNF-α gene polymorphisms in patients with peri-implantitis and healthy controls.Semantic proximity Read ↗

Genetic variants in genes of the inflammatory response in association with infective endocarditis.Semantic proximity Read ↗

Association of cytokines polymorphisms with chronic peridontitis and rheumatoid arthritis in a Mexican population.Semantic proximity Read ↗

[Polymorphisms related to SIRS and inflammatory response].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.