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Article

Gene of the month: <i>BAP1</i>

27 May 2016

Abstract excerpt

The BAP1 gene (BRCA1-associated protein 1) is a tumour suppressor gene that encodes a deubiquitinating enzyme (DUB), regulating key cellular pathways, including cell cycle, cellular differentiation, transcription and DNA damage response. Germline BAP1 mutations cause a novel cancer syndrome characterised by early onset of multiple atypical Spitz tumours and increased risk of uveal and cutaneous melanoma,...

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Identifiers

PMID: 27235536
DOI: 10.1136/jclinpath-2016-203866

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