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Article

Mendelian randomization study on the causal effects of systemic lupus erythematosus on major depressive disorder.

Journal of human genetics - 1 Jan 2023

Li Wenchang, Kan Hoktim, Zhang Weizhe, Zhong Yanlin, Liao Weiming, Huang Guiwu, Wu Peihui

Abstract excerpt

The vast majority of epidemiological studies suggested a link between systemic lupus erythematosus (SLE) and major depressive disorder (MDD). However, the causality for SLE on the risk of MDD remained unknown due to confounding factors or reverse causality. Herein, we investigated the causality between SLE and MDD in those of European ancestry by a Mendelian randomization (MR) approach. Summary genetic data of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 36316471
DOI: 10.1038/s10038-022-01080-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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