Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hereditary variants of unknown significance in African American women with breast cancer.

PloS one - 1 Jan 2022

McDonald J Tyson, Ricks-Santi Luisel J

Abstract excerpt

Expanded implementation of genetic sequencing has precipitously increased the discovery of germline and somatic variants. The direct benefit of identifying variants in actionable genes may lead to risk reduction strategies such as increased surveillance, prophylactic surgery, as well as lifestyle modifications to reduce morbidity and mortality. However, patients with African ancestry are more likely to receive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Testing
Share to Black or African American
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Breast Neoplasms

Share to Exome Sequencing

Share to Genes, BRCA2

Share to Germ-Line Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 36315513
DOI: 10.1371/journal.pone.0273835
PMCID: PMC9621418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hereditary variants of unknown significance in African American women with breast cancer.PMID 36315513Read ↗

Next Generation Sequencing Reveals High Prevalence of BRCA1 and BRCA2 Variants of Unknown Significance in Early-Onset Breast Cancer in African American Women.Semantic proximity Read ↗

BRCA1 and BRCA2 pathogenic sequence variants in women of African origin or ancestry.Semantic proximity Read ↗

Frequency and spectrum of mutations across 94 cancer predisposition genes in African American women with invasive breast cancer.Semantic proximity Read ↗

Hereditary ovarian cancer in women with African ancestry: a scoping review.Semantic proximity Read ↗

Inherited predisposition to breast cancer among African American women.Semantic proximity Read ↗

Disparate Rates of Germline Variants in Cancer Predisposition Genes in African American/Black Compared With Non-Hispanic White Individuals Between 2015 and 2022.Semantic proximity Read ↗

Heritable Susceptibility to Breast Cancer among African-American Women in the Detroit Research on Cancer Survivors Study.Semantic proximity Read ↗

Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.Semantic proximity Read ↗

Germline variants of uncertain significance, their frequency, and clinico-pathological features in a cohort of Sri Lankan patients with hereditary breast cancer.Semantic proximity Read ↗

Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers.Semantic proximity Read ↗

Breast cancer genetics in African Americans.Semantic proximity Read ↗

An exome-wide analysis of low frequency and rare variants in relation to risk of breast cancer in African American Women: the AMBER Consortium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.