Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Next Generation Sequencing Reveals High Prevalence of BRCA1 and BRCA2 Variants of Unknown Significance in Early-Onset Breast Cancer in African American Women.

Ethnicity & disease - 1 Jan 2017

Ricks-Santi Luisel, McDonald J Tyson, Gold Bert, Dean Michael, Thompson Nicole, Abbas Muneer, Wilson Bradford, Kanaan Yasmine, Naab Tammey J, Dunston Georgia

Abstract excerpt

BACKGROUND: Variants of unknown significance (VUSs) have been identified in BRCA1 and BRCA2 and account for the majority of all identified sequence alterations. Notably, VUSs occur disproportionately in people of African descent hampering breast cancer (BCa) management and prevention efforts in the population. Our study sought to identify and characterize mutations associated with increased risk of BCa at young...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA1 Protein

Share to BRCA2 Protein

Share to DNA, Neoplasm

Share to High-Throughput Nucleotide Sequencing

Share to Prevalence

Share to United States

Source

Open in PubMed Open full text

Identifiers

PMID: 28439188
DOI: 10.18865/ed.27.2.169
PMCID: PMC5398176

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Next Generation Sequencing Reveals High Prevalence of BRCA1 and BRCA2 Variants of Unknown Significance in Early-Onset Breast Cancer in African American Women.PMID 28439188Read ↗

Hereditary variants of unknown significance in African American women with breast cancer.Semantic proximity Read ↗

Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to white women.Semantic proximity Read ↗

BRCA1 and BRCA2 mutations in a study of African American breast cancer patients.Semantic proximity Read ↗

BRCA1 and BRCA2 pathogenic sequence variants in women of African origin or ancestry.Semantic proximity Read ↗

Inherited predisposition to breast cancer among African American women.Semantic proximity Read ↗

Breast cancer in West Africa: molecular analysis of BRCA genes in early-onset breast cancer patients in Burkina Faso.Semantic proximity Read ↗

Breast cancer genetics in African Americans.Semantic proximity Read ↗

Frequency and spectrum of mutations across 94 cancer predisposition genes in African American women with invasive breast cancer.Semantic proximity Read ↗

Germline sequence variants contributing to cancer susceptibility in South African breast cancer patients of African ancestry.Semantic proximity Read ↗

Breast cancer in Western Africa: A pilot molecular analysis of BRCA genes in early- onset breast cancer patients in Burkina FasoSemantic proximity Read ↗

Breast cancer in young women (YBC): prevalence of BRCA1/2 mutations and risk of secondary malignancies across diverse racial groups.Semantic proximity Read ↗

A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.