Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disparate Rates of Germline Variants in Cancer Predisposition Genes in African American/Black Compared With Non-Hispanic White Individuals Between 2015 and 2022.

JCO precision oncology - 1 Jul 2024

Wyatt Castillo Rachel B, Nielsen Sarah M, Chen Elaine, Heald Brandie, Ellsworth Rachel E, Esplin Edward D, Tomlinson Gail E

Abstract excerpt

PURPOSE: African American/Black (AA/B) individuals are under-represented in genomic databases and thus less likely to receive definitive information from germline genetic testing (GGT) than non-Hispanic White (NHW) individuals. With nearly 500,000 AA/B and NHW individuals having undergone multigene panel testing (MGPT) for hereditary cancer risk at a single commercial laboratory, to our knowledge, we present the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to PALB2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PMS2 gene

Share to Genetic Predisposition to Disease

Share to Genetic Testing

Share to Germ-Line Mutation

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 38991178
DOI: 10.1200/PO.23.00715
PMCID: PMC12085080

Genes

BRCA1
BRCA2
PALB2
ATM
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disparate Rates of Germline Variants in Cancer Predisposition Genes in African American/Black Compared With Non-Hispanic White Individuals Between 2015 and 2022.PMID 38991178Read ↗

Frequency and spectrum of mutations across 94 cancer predisposition genes in African American women with invasive breast cancer.Semantic proximity Read ↗

Prevalence of Pathogenic Germline Variants in Cancer Susceptibility Genes using the All of Us DatasetSemantic proximity Read ↗

Mutation prevalence tables for hereditary cancer derived from multi-gene panel testingSemantic proximity Read ↗

Germline Variant Spectrum Among African American Men Undergoing Prostate Cancer Germline Testing: Need for Equity in Genetic TestingSemantic proximity Read ↗

Risks and Implications of Multiple Actionable Pathogenic Germline Variants Discovered by Panel-Based Cancer Predisposition Testing.Semantic proximity Read ↗

Hereditary cancer testing in a diverse sample across three breast imaging centers.Semantic proximity Read ↗

Germline variant spectrum of hereditary cancer susceptibility genes in a Chinese cohort.Semantic proximity Read ↗

Mutation prevalence tables for hereditary cancer derived from multigene panel testing.Semantic proximity Read ↗

Racial and ethnic variation in multigene panel testing in a cohort of BRCA1/2-negative individuals who had genetic testing in a large urban comprehensive cancer center.Semantic proximity Read ↗

BRCA1 and BRCA2 pathogenic sequence variants in women of African origin or ancestry.Semantic proximity Read ↗

Racial and Ethnic variation in BRCA1 and BRCA2 genetic test results among individuals referred for genetic counseling at a large urban comprehensive cancer centerSemantic proximity Read ↗

Genetic Testing and Results in a Population-Based Cohort of Breast Cancer Patients and Ovarian Cancer PatientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.