Article
An in silico analysis of the impact of POLE mutations on cladribine docking.
European review for medical and pharmacological sciences - 1 Oct 2022
Loganathan L, Al-Haidose A, Ganesh Kumar A, Sujatha L B, Carlus F H, Alharbi A, Alhyassat S, Muthusamy K, Carlus S J, Abdallah A M
Abstract excerpt
OBJECTIVE: Polymerase ε exonuclease (POLE) is an enzyme involved in DNA replication and may be an attractive therapeutic target in various cancers. Here we sought to model the impact of specific POLE mutations on protein function. Due to the lack of a crystal structure, the tertiary structures of the wild type and four common mutants were modeled using I-Tasser server. MATERIALS AND METHODS: Molecular docking and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.