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Article

Interpreting the effects of DNA polymerase variants at the structural level.

Molecular oncology - 1 Aug 2026

Arnaudi Matteo, Krzesińska Karolina, Beltrame Ludovica, Besora Pablo Sánchez-Izquierdo, Tiberti Matteo, Nilbert Mef, Rohlin Anna, Papaleo Elena

Abstract excerpt

Genetic variants in the DNA polymerase enzymes POLE and POLD1 can affect protein function by altering stability, catalysis, DNA binding, and interactions with other biomolecules. Understanding the structural basis of these variants is important for a comprehensive interpretation of variant impact. In this study, we used MAVISp, a modular structure-based framework, and molecular dynamics simulations to analyze...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42204826
DOI: 10.1002/1878-0261.70255
PMCID: PMC13398764

Genes

POLE
POLD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Interpreting the effects of DNA polymerase variants at the structural level.PMID 42204826Read ↗

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