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Article

DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer.

Human molecular genetics - 15 Jul 2013

Church David N, Briggs Sarah E W, Palles Claire, Domingo Enric, Kearsey Stephen J, Grimes Jonathon M, Gorman Maggie, Martin Lynn, Howarth Kimberley M, Hodgson Shirley V, Kaur Kulvinder, Taylor Jenny, Tomlinson Ian P M

Abstract excerpt

Accurate duplication of DNA prior to cell division is essential to suppress mutagenesis and tumour development. The high fidelity of eukaryotic DNA replication is due to a combination of accurate incorporation of nucleotides into the nascent DNA strand by DNA polymerases, the recognition and removal of mispaired nucleotides (proofreading) by the exonuclease activity of DNA polymerases δ and ε, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23528559
DOI: 10.1093/hmg/ddt131
PMCID: PMC3690967

Genes

POLE
POLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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