Article
Altered transcription factor targeting is associated with differential peripheral blood mononuclear cell proportions in sarcoidosis
13 Oct 2022
Abstract excerpt
Introduction: In sarcoidosis, peripheral lymphopenia and anergy have been associated with increased inflammation and maladaptive immune activity, likely promoting development of chronic and progressive disease. However, the molecular mechanisms that lead to reduced lymphocyte proportions, particularly CD4+ T-cells, have not been fully elucidated. We posit that paradoxical peripheral lymphopenia is characterized...
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