Article

Severe Sarcoidosis Demonstrates Heterogenous Immune Dysregulation Across Different Peripheral Immune Cell Types: A Single-Center Single Cell Multi-omic Analysis

2024-09-19

Abstract excerpt

Sarcoidosis provides unique management challenges due to variable presentation and disease course. In this single-center analysis, we assess transcriptomic and epigenomic differentiators between severe and mild cases of sarcoidosis using peripheral blood. We showcase differences across multiple cell types that highlight decreased immunoregulation and increased inflammation in severe sarcoidosis. We provide an over...

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Literature Corpus work: 946a6748-bfbc-5287-8c27-f89ac34b668e
DOI: 10.1101/2024.09.18.24313886

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