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Article

Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis.

PloS one - 1 Jan 2012

Zhou Tong, Zhang Wei, Sweiss Nadera J, Chen Edward S, Moller David R, Knox Kenneth S, Ma Shwu-Fan, Wade Michael S, Noth Imre, Machado Roberto F, Garcia Joe G N

Abstract excerpt

Sarcoidosis, a systemic granulomatous syndrome invariably affecting the lung, typically spontaneously remits but in ~20% of cases progresses with severe lung dysfunction or cardiac and neurologic involvement (complicated sarcoidosis). Unfortunately, current biomarkers fail to distinguish patients with remitting (uncomplicated) sarcoidosis from other fibrotic lung disorders, and fail to identify individuals at...

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Identifiers

PMID: 22984568
DOI: 10.1371/journal.pone.0044818
PMCID: PMC3440319

Genes

AKT3
CBLB
DLG1
IFNG
ITK
JUN
MALT1
NFATC2
NOG
PLCG1
SPRED1
TSHZ2

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