Article
Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation.
Laboratory investigation; a journal of technical methods and pathology - 1 May 2022
Watanabe Masahito, Umeyama Kazuhiro, Nakano Kazuaki, Matsunari Hitomi, Fukuda Toru, Matsumoto Kei, Tajiri Susumu, Yamanaka Shuichiro, Hasegawa Koki, Okamoto Kazutoshi, Uchikura Ayuko, Takayanagi Shuko, Nagaya Masaki, Yokoo Takashi, Nakauchi Hiromitsu, Nagashima Hiroshi
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease, manifesting as the progressive development of fluid-filled renal cysts. In approximately half of all patients with ADPKD, end-stage renal disease results in decreased renal function. In this study, we used CRISPR-Cas9 and somatic cell cloning to produce pigs with the unique mutation c.152_153insG (PKD1insG/+)....
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