Article
HAT: haplotype assembly tool using short and error-prone long reads.
Bioinformatics (Oxford, England) - 13 Dec 2022
Shirali Hossein Zade Ramin, Urhan Aysun, Assis de Souza Alvaro, Singh Akash, Abeel Thomas
Abstract excerpt
MOTIVATION: Haplotypes are the set of alleles co-occurring on a single chromosome and inherited together to the next generation. Because a monoploid reference genome loses this co-occurrence information, it has limited use in associating phenotypes with allelic combinations of genotypes. Therefore, methods to reconstruct the complete haplotypes from DNA sequencing data are crucial. Recently, several attempts have...
Topics
- Haplotypes
- High-Throughput Nucleotide Sequencing
- Tool Use Behavior
- Sequence Analysis, DNA
- Alleles
- Algorithms