Article
HapCol: accurate and memory-efficient haplotype assembly from long reads.
Bioinformatics (Oxford, England) - 1 Jun 2016
Pirola Yuri, Zaccaria Simone, Dondi Riccardo, Klau Gunnar W, Pisanti Nadia, Bonizzoni Paola
Abstract excerpt
MOTIVATION: Haplotype assembly is the computational problem of reconstructing haplotypes in diploid organisms and is of fundamental importance for characterizing the effects of single-nucleotide polymorphisms on the expression of phenotypic traits. Haplotype assembly highly benefits from the advent of 'future-generation' sequencing technologies and their capability to produce long reads at increasing coverage....
Topics
- Algorithms
- Diploidy
- Haplotypes
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA
- Software